1 ABRAX study
1.1 Inclusion criteria
1.1.1 Histologically confirmed invasive cervical cancer (Squamous cell carcinoma, Adenocarcinoma, Adenosquamous carcinoma) [No,Yes]
1.1.2 Stage pT1a – pT2b [No,Yes]
1.1.3 Patient referred for primary surgical treatment (including radical / simple hysterectomy / fertility sparing procedure) in combination with LN staging. [No,Yes]
1.1.4 Intraoperative detection of LN involvement (micrometastases or macrometastases). Grossly involved lymph nodes OR SLN/LN intraoperative pathologic evaluation (frozen section). [No,Yes]
1.1.5 Follow-up data available for ≥ 2 years [No,Yes]
1.1.6 Surgery performed between January 2005 and December 2015 [No,Yes]
1.2 Patient´s identification and history
1.2.1 Date of birth (month/year)
1.2.2 Second primary cancer (previous or simultaneous)
1.2.2.1 Breast cancer [No,Yes]
1.2.2.1.1 Date of diagnosis (year)
1.2.2.1.2 Treatment
1.2.2.1.2.1 Chemotherapy [No,Yes]
1.2.2.1.2.2 Radiotherapy [No,Yes]
1.2.2.1.2.2.1 Location
1.2.2.1.2.2.1.1 Abdominal [No,Yes]
1.2.2.1.2.2.1.2 Pelvic [No,Yes]
1.2.2.1.2.2.1.3 Other fields [No,Yes]
1.2.2.1.2.3 Surgery [No,Yes]
1.2.2.2 Haematological malignancy [No,Yes]
1.2.2.2.1 Date of diagnosis (year)
1.2.2.2.2 Treatment
1.2.2.2.2.1 Chemotherapy [No,Yes]
1.2.2.2.2.2 Radiotherapy [No,Yes]
1.2.2.2.2.2.1 Location
1.2.2.2.2.2.1.1 Abdominal [No,Yes]
1.2.2.2.2.2.1.2 Pelvic [No,Yes]
1.2.2.2.2.2.1.3 Other fields [No,Yes]
1.2.2.2.2.3 Surgery [No,Yes]
1.2.2.3 Other [No,Yes]
1.2.2.3.1 Cancer type description
1.2.2.3.2 Date of diagnosis (year)
1.2.2.3.3 Treatment
1.2.2.3.3.1 Chemotherapy [No,Yes]
1.2.2.3.3.2 Radiotherapy [No,Yes]
1.2.2.3.3.2.1 Location
1.2.2.3.3.2.1.1 Abdominal [No,Yes]
1.2.2.3.3.2.1.2 Pelvic [No,Yes]
1.2.2.3.3.2.1.3 Other fields [No,Yes]
1.2.2.3.3.3 Surgery [No,Yes]
1.2.3 Height (at the time of diagnosis)
1.2.4 Weight (at the time of diagnosis)
1.2.5 Performance status (ECOG at the time of diagnosis) [0,1,2,3,4,Not available]
1.3 Diagnostics
1.3.1 Date of first diagnosis (month/year)
1.3.2 Diagnostic procedure [Biopsy,Conization (any technique including LEEP, LLETZ etc.),Other,Pap smear]
1.3.3 Imaging method used for clinical staging before primary surgery
1.3.3.1 CT [No,Yes]
1.3.3.2 Expert sonography [No,Yes]
1.3.3.3 MRI [No,Yes]
1.3.3.4 PET [No,Yes]
1.3.3.5 None [No,Yes]
1.3.3.6 Not available [No,Yes]
1.3.4 Pre-treatment clinical and radiological staging (TNM classification) [T1A1,T1A2,T1B1,T1B2,T2A1,T2A2,T2B]
1.3.5 Largest tumor size on radiological staging
1.3.6 Lymph nodes radiological staging [Normal,Not assessed,Not available]
1.3.7 Histological type [Adeno,Adenosquamous,Other,Squamous]
1.3.8 Horizontal dimension
1.3.9 Depth of invasion
1.4 Treatment
1.4.1 Neoadjuvant chemotherapy was given [No,Yes]
1.4.2 Neoadjuvant chemotherapy
1.4.2.1 Regimen
1.4.2.1.1 Carboplatin [No,Yes]
1.4.2.1.1.1 Dose per cycle
1.4.2.1.1.2 No of cycles [1,2,3,4,5]
1.4.2.1.2 Paclitaxel [No,Yes]
1.4.2.1.2.1 Dose per cycle
1.4.2.1.2.2 No of cycles [1,2,3,4,5]
1.4.2.1.3 Cisplatin [No,Yes]
1.4.2.1.3.1 Dose per cycle
1.4.2.1.3.2 No of cycles [1,2,3,4,5]
1.4.2.1.4 Ifosfamide [No,Yes]
1.4.2.1.4.1 Dose per cycle
1.4.2.1.4.2 No of cycles [1,2,3,4,5]
1.4.2.1.5 Etoposide [No,Yes]
1.4.2.1.5.1 Dose per cycle
1.4.2.1.5.2 No of cycles [1,2,3,4,5]
1.4.2.1.6 Other [No,Yes]
1.4.2.1.6.1 Regimen description
1.4.3 Primary surgery
1.4.3.1 Surgery date (month/year)
1.4.3.2 Intraoperative detection of LN involvement (micrometastases or macrometastases)
1.4.3.2.1 Macroscopic involvement = grossly involved lymph nodes (if confirmed by final pathology) [No,Yes]
1.4.3.2.2 Microscopic involvement = SLN / LN intraoperative pathologic evaluation (frozen section) [No,Yes]
1.4.3.3 Intraoperative histological evaluation of LN (frozen section)
1.4.3.3.1 Type of LN submitted [Pelvic nonSLN lymph node(s),SLN]
1.4.3.3.2 Selection of LN for frozen section [All harvested LN submitted,Anatomical localisation,Not available,SLN,Suspicious LN]
1.4.3.3.3 No of SLN/LN evaluated intraoperatively
1.4.3.3.4 Type of metastasis reported from intraoperative evaluation (enter the largest type) [Macrometastases,Micrometastases]
1.4.3.4 Cervical/uterine procedure abandoned [No,Yes]
1.4.3.5 Reasons for abandoning cervical/uterine procedure
1.4.3.5.1 Distant metastatic spread of tumor [No,Yes]
1.4.3.5.2 LN involvement [No,Yes]
1.4.3.5.3 Local tumor spread [No,Yes]
1.4.3.5.4 Other [No,Yes]
1.4.3.5.4.1 Description
1.4.4 Primary treatment
1.4.4.1 Cervical/uterine procedure [Conization (any technique including LEEP, LLETZ etc.),Radical hysterectomy (including parametrectomy),Radical trachelectomy (including parametrectomy),Simple hysterectomy,Simple trachelectomy (cervix amputation without parametrectomy)]
1.4.4.2 Parametrectomy (applied for radical hysterectomy and radical trachelectomy)
1.4.4.2.1 Type [Nerve sparing,Not classified,Other,Simple hysterectomy,TMMR,Type A,Type B,Type C1,Type C2,Type D,Type II,Type III]
1.4.4.2.2 Description
1.4.4.3 Adnexal procedure
1.4.4.3.1 Type [Adnexal preservation,BSO,Previous BSO,Salpingectomy and ovarian preservation]
1.4.4.3.2 Extrapelvic transposition [No,Yes]
1.4.4.4 Surgical approach [Laparo-vaginal,Laparoscopic,Open (laparotomy),Robotic,Vaginal]
1.4.4.5 Lymph node staging
1.4.4.5.1 SLN biopsy
1.4.4.5.1.1 SLN biopsy was done [No,Yes]
1.4.4.5.1.2 Laterality [Bilat,Unilat]
1.4.4.5.2 Pelvic lymphadenectomy
1.4.4.5.2.1 Pelvic lymphadenectomy was performed [No,Yes]
1.4.4.6 Paraaortic lymphadenectomy
1.4.4.6.1 Paraaortic lymphadenectomy was performed [No,Yes]
1.4.4.6.2 Location
1.4.4.6.2.1 Inframesenterial (below arteria mesenterica inferior) [No,Yes]
1.4.4.6.2.2 Supramesenterial (up to the renal vessels) [No,Yes]
1.4.4.7 Final histological report
1.4.4.7.1 Cervix/Uterus
1.4.4.7.1.1 Size of the tumor
1.4.4.7.1.1.1 Largest tumor dimension (Sum of largest dimension of the specimen from therapeutic and diagnostic procedures)
1.4.4.7.1.2 LVSI [No,Yes]
1.4.4.7.2 Parametrial invasion
1.4.4.7.2.1 Parametrial invasion detected [No,Yes]
1.4.4.7.2.2 Laterality [Bilat,Unilat]
1.4.4.7.3 Free vaginal margins [No,Yes]
1.4.4.7.4 Final lymph node status
1.4.4.7.4.1 SLN [No,Yes]
1.4.4.7.4.1.1 No of SLN removed
1.4.4.7.4.1.2 No of SLN with metastases
1.4.4.7.4.1.3 SLN ultrastaging was performed [No,Yes]
1.4.4.7.4.1.4 Type of metastases (enter the largest type) [Isolated tumor cells,Macrometastases,Micrometastases]
1.4.4.7.4.2 Non-SLN pelvic LNs [No,Yes]
1.4.4.7.4.2.1 No of LN removed
1.4.4.7.4.2.2 No of LN with metastases
1.4.4.7.4.2.3 Type of metastases (enter the largest type) [Isolated tumor cells,Macrometastases,Micrometastases]
1.4.4.7.4.2.4 Size of the largest macrometastases
1.4.4.7.4.3 Paraaortic LNs (if PALD performed) [No,Yes]
1.4.4.7.4.3.1 No of LN removed
1.4.4.7.4.3.2 No of LN with metastases
1.4.4.7.4.3.3 Type of metastases (enter the largest type) [Isolated tumor cells,Macrometastases,Micrometastases]
1.4.4.8 Surgical data
1.4.4.8.1 Operation time
1.4.4.8.2 Blood loss
1.4.4.8.3 Surgical complication
1.4.4.8.3.1 Bowel injury [No,Yes]
1.4.4.8.3.2 Ureteral injury [No,Yes]
1.4.4.8.3.3 Urinary bladder injury [No,Yes]
1.4.4.8.3.4 Other [No,Yes]
1.4.4.8.3.4.1 Description
1.4.4.8.4 Serious early postoperative adverse-events ≥ 2 according to CTCAE grading (until 30th postoperative day)
1.4.4.8.4.1 1. adverse event [No,Yes]
1.4.4.8.4.1.1 Type [Blood,Gastrointestinal,Infections,Other,Renal,Respiratory,Skin,Surgical,Vascular]
1.4.4.8.4.1.2 Grade [2,3,4,5]
1.4.4.8.4.2 2. adverse event [No,Yes]
1.4.4.8.4.2.1 Type [Blood,Gastrointestinal,Infections,Other,Renal,Respiratory,Skin,Surgical,Vascular]
1.4.4.8.4.2.2 Grade [2,3,4,5]
1.4.4.8.4.3 3. adverse event [No,Yes]
1.4.4.8.4.3.1 Type [Blood,Gastrointestinal,Infections,Other,Renal,Respiratory,Skin,Surgical,Vascular]
1.4.4.8.4.3.2 Grade [2,3,4,5]
1.4.4.8.4.4 4. adverse event [No,Yes]
1.4.4.8.4.4.1 Type [Blood,Gastrointestinal,Infections,Other,Renal,Respiratory,Skin,Surgical,Vascular]
1.4.4.8.4.4.2 Grade [2,3,4,5]
1.4.4.8.4.5 5. adverse event [No,Yes]
1.4.4.8.4.5.1 Type [Blood,Gastrointestinal,Infections,Other,Renal,Respiratory,Skin,Surgical,Vascular]
1.4.4.8.4.5.2 Grade [2,3,4,5]
1.4.4.9 Type of primary treatment [Chemotherapy only,Other,Radiochemotherapy,Radiotherapy only]
1.4.4.10 Description of treatment
1.4.4.11 External beam radiotherapy [No,Yes]
1.4.4.11.1 Type [2D,3D,IMRT]
1.4.4.11.2 Machine [Cobalt source,Linear accelerator]
1.4.4.11.3 Area treated [Extended to paraaortic LN,Pelvis only]
1.4.4.11.4 Duration
1.4.4.11.5 Total dose
1.4.4.11.6 Number of fractions
1.4.4.12 Brachytherapy [No,Yes]
1.4.4.12.1 Type [High dose rate,Low dose rate,PDR]
1.4.4.12.2 Total dose
1.4.4.12.3 Number of fractions
1.4.4.13 Concomitant chemotherapy
1.4.4.13.1 Regimen
1.4.4.13.1.1 Carboplatin [No,Yes]
1.4.4.13.1.1.1 Dose per cycle
1.4.4.13.1.1.2 No of cycles [1,2,3,4,5]
1.4.4.13.1.2 Cisplatin [No,Yes]
1.4.4.13.1.2.1 Dose per cycle
1.4.4.13.1.2.2 No of cycles [1,2,3,4,5]
1.4.4.13.1.3 Other [No,Yes]
1.4.4.13.1.3.1 Description
1.4.4.14 Overall treatment (radiotherapy) time
1.4.4.15 Reason why concomitant chemotherapy was not applied
1.4.4.15.1 Impaired renal function [No,Yes]
1.4.4.15.2 Local standard [No,Yes]
1.4.4.15.3 Poor performance status [No,Yes]
1.4.4.15.4 Other [No,Yes]
1.4.4.15.4.1 Description
1.4.4.16 Regimen
1.4.4.16.1 Carboplatin [No,Yes]
1.4.4.16.1.1 Dose per cycle
1.4.4.16.1.2 No of cycles [1,2,3,4,5]
1.4.4.16.2 Cisplatin [No,Yes]
1.4.4.16.2.1 Dose per cycle
1.4.4.16.2.2 No of cycles [1,2,3,4,5]
1.4.4.16.3 Docetaxel [No,Yes]
1.4.4.16.3.1 Dose per cycle
1.4.4.16.3.2 No of cycles [1,2,3,4,5]
1.4.4.16.4 Paclitaxel [No,Yes]
1.4.4.16.4.1 Dose per cycle
1.4.4.16.4.2 No of cycles [1,2,3,4,5]
1.4.4.16.5 Topotecan [No,Yes]
1.4.4.16.5.1 Dose per cycle
1.4.4.16.5.2 No of cycles [1,2,3,4,5]
1.4.4.16.6 Other [No,Yes]
1.4.4.16.6.1 Description
1.4.4.17 Reason why radiotherapy was not given
1.4.4.17.1 Impaired renal function [No,Yes]
1.4.4.17.2 Local standard [No,Yes]
1.4.4.17.3 Poor performance status [No,Yes]
1.4.4.17.4 Other [No,Yes]
1.4.4.17.4.1 Description
1.4.5 Adjuvant treatment was given [No,Yes]
1.4.6 Adjuvant treatment
1.4.6.1 Indication
1.4.6.1.1 LN involvement [No,Yes]
1.4.6.1.2 Parametrial involvement [No,Yes]
1.4.6.1.3 Sedlis criteria (high risk tumor based on the size, stromal invasion, LVSI) [No,Yes]
1.4.6.1.4 Other [No,Yes]
1.4.6.2 Type of adjuvant treatment [Chemotherapy only,Other,Radiochemotherapy,Radiotherapy only]
1.4.6.3 Description of adjuvant treatment
1.4.6.4 Brachytherapy [No,Yes]
1.4.6.4.1 Type [High dose rate,Low dose rate,PDR]
1.4.6.4.2 Total dose
1.4.6.4.3 Number of fractions
1.4.6.5 Date when adjuvant treatment was finished (month/year)
1.4.6.6 External beam radiotherapy [No,Yes]
1.4.6.6.1 Type [2D,3D,IMRT]
1.4.6.6.2 Machine [Cobalt source,Linear accelerator]
1.4.6.6.3 Area treated [Extended to paraaortic LN,Pelvis only]
1.4.6.6.4 Duration
1.4.6.6.5 Total dose
1.4.6.6.6 Number of fractions
1.4.6.7 Concomitant chemotherapy
1.4.6.7.1 Regimen
1.4.6.7.1.1 Carboplatin [No,Yes]
1.4.6.7.1.1.1 Dose per cycle
1.4.6.7.1.1.2 No of cycles [1,2,3,4,5]
1.4.6.7.1.2 Cisplatin [No,Yes]
1.4.6.7.1.2.1 Dose per cycle
1.4.6.7.1.2.2 No of cycles [1,2,3,4,5]
1.4.6.7.1.3 Other [No,Yes]
1.4.6.7.1.3.1 Description
1.4.6.8 Overall treatment (radiotherapy) time
1.4.6.9 Reason why concomitant chemotherapy was not applied
1.4.6.9.1 Impaired renal function [No,Yes]
1.4.6.9.2 Local standard [No,Yes]
1.4.6.9.3 Poor performance status [No,Yes]
1.4.6.9.4 Other [No,Yes]
1.4.6.9.4.1 Description
1.4.6.10 Regimen
1.4.6.10.1 Carboplatin [No,Yes]
1.4.6.10.1.1 Dose per cycle
1.4.6.10.1.2 No of cycles [1,2,3,4,5]
1.4.6.10.2 Docetaxel [No,Yes]
1.4.6.10.2.1 Dose per cycle
1.4.6.10.2.2 No of cycles [1,2,3,4,5]
1.4.6.10.3 Paclitaxel [No,Yes]
1.4.6.10.3.1 Dose per cycle
1.4.6.10.3.2 No of cycles [1,2,3,4,5]
1.4.6.10.4 Cisplatin [No,Yes]
1.4.6.10.4.1 Dose per cycle
1.4.6.10.4.2 No of cycles [1,2,3,4,5]
1.4.6.10.5 Topotecan [No,Yes]
1.4.6.10.5.1 Dose per cycle
1.4.6.10.5.2 No of cycles [1,2,3,4,5]
1.4.6.10.6 Other [No,Yes]
1.4.6.10.6.1 Description
1.4.6.11 Reason why radiotherapy was not given
1.4.6.11.1 Impaired renal function [No,Yes]
1.4.6.11.2 Local standard [No,Yes]
1.4.6.11.3 Poor performance status [No,Yes]
1.4.6.11.4 Other [No,Yes]
1.4.6.11.4.1 Description
1.4.7 Date when treatment was finished (month/year)
1.4.8 Method used for the response to definitive treatment assessment
1.4.8.1 CT [No,Yes]
1.4.8.2 MRI [No,Yes]
1.4.8.3 PET [No,Yes]
1.4.8.4 Physical examination [No,Yes]
1.4.8.5 US [No,Yes]
1.4.9 Definitive treatment outcome [Complete response,Partial response,Progressive disease,Stable disease]
1.5 Follow-up
1.5.1 Follow-up procedure
1.5.1.1 CT [No,Yes]
1.5.1.1.1 1. year [No,Yes]
1.5.1.1.1.1 If clinically indicated [No,Yes]
1.5.1.1.1.2 Routinely [No,Yes]
1.5.1.1.1.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.1.2 2. year [No,Yes]
1.5.1.1.2.1 If clinically indicated [No,Yes]
1.5.1.1.2.2 Routinely [No,Yes]
1.5.1.1.2.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.1.3 3. year [No,Yes]
1.5.1.1.3.1 If clinically indicated [No,Yes]
1.5.1.1.3.2 Routinely [No,Yes]
1.5.1.1.3.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.1.4 4. year [No,Yes]
1.5.1.1.4.1 If clinically indicated [No,Yes]
1.5.1.1.4.2 Routinely [No,Yes]
1.5.1.1.4.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.1.5 5. year [No,Yes]
1.5.1.1.5.1 If clinically indicated [No,Yes]
1.5.1.1.5.2 Routinely [No,Yes]
1.5.1.1.5.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.2 Expert ultrasound [No,Yes]
1.5.1.2.1 1. year [No,Yes]
1.5.1.2.1.1 If clinically indicated [No,Yes]
1.5.1.2.1.2 Routinely [No,Yes]
1.5.1.2.1.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.2.2 2. year [No,Yes]
1.5.1.2.2.1 If clinically indicated [No,Yes]
1.5.1.2.2.2 Routinely [No,Yes]
1.5.1.2.2.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.2.3 3. year [No,Yes]
1.5.1.2.3.1 If clinically indicated [No,Yes]
1.5.1.2.3.2 Routinely [No,Yes]
1.5.1.2.3.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.2.4 4. year [No,Yes]
1.5.1.2.4.1 If clinically indicated [No,Yes]
1.5.1.2.4.2 Routinely [No,Yes]
1.5.1.2.4.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.2.5 5. year [No,Yes]
1.5.1.2.5.1 If clinically indicated [No,Yes]
1.5.1.2.5.2 Routinely [No,Yes]
1.5.1.2.5.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.3 Gynecological examination [No,Yes]
1.5.1.3.1 1. year [No,Yes]
1.5.1.3.1.1 If clinically indicated [No,Yes]
1.5.1.3.1.2 Routinely [No,Yes]
1.5.1.3.1.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.3.2 2. year [No,Yes]
1.5.1.3.2.1 If clinically indicated [No,Yes]
1.5.1.3.2.2 Routinely [No,Yes]
1.5.1.3.2.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.3.3 3. year [No,Yes]
1.5.1.3.3.1 If clinically indicated [No,Yes]
1.5.1.3.3.2 Routinely [No,Yes]
1.5.1.3.3.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.3.4 4. year [No,Yes]
1.5.1.3.4.1 If clinically indicated [No,Yes]
1.5.1.3.4.2 Routinely [No,Yes]
1.5.1.3.4.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.3.5 5. year [No,Yes]
1.5.1.3.5.1 If clinically indicated [No,Yes]
1.5.1.3.5.2 Routinely [No,Yes]
1.5.1.3.5.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.4 HPV test [No,Yes]
1.5.1.4.1 1. year [No,Yes]
1.5.1.4.1.1 If clinically indicated [No,Yes]
1.5.1.4.1.2 Routinely [No,Yes]
1.5.1.4.1.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.4.2 2. year [No,Yes]
1.5.1.4.2.1 If clinically indicated [No,Yes]
1.5.1.4.2.2 Routinely [No,Yes]
1.5.1.4.2.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.4.3 3. year [No,Yes]
1.5.1.4.3.1 If clinically indicated [No,Yes]
1.5.1.4.3.2 Routinely [No,Yes]
1.5.1.4.3.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.4.4 4. year [No,Yes]
1.5.1.4.4.1 If clinically indicated [No,Yes]
1.5.1.4.4.2 Routinely [No,Yes]
1.5.1.4.4.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.4.5 5. year [No,Yes]
1.5.1.4.5.1 If clinically indicated [No,Yes]
1.5.1.4.5.2 Routinely [No,Yes]
1.5.1.4.5.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.5 MRI [No,Yes]
1.5.1.5.1 1. year [No,Yes]
1.5.1.5.1.1 If clinically indicated [No,Yes]
1.5.1.5.1.2 Routinely [No,Yes]
1.5.1.5.1.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.5.2 2. year [No,Yes]
1.5.1.5.2.1 If clinically indicated [No,Yes]
1.5.1.5.2.2 Routinely [No,Yes]
1.5.1.5.2.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.5.3 3. year [No,Yes]
1.5.1.5.3.1 If clinically indicated [No,Yes]
1.5.1.5.3.2 Routinely [No,Yes]
1.5.1.5.3.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.5.4 4. year [No,Yes]
1.5.1.5.4.1 If clinically indicated [No,Yes]
1.5.1.5.4.2 Routinely [No,Yes]
1.5.1.5.4.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.5.5 5. year [No,Yes]
1.5.1.5.5.1 If clinically indicated [No,Yes]
1.5.1.5.5.2 Routinely [No,Yes]
1.5.1.5.5.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.6 PET-CT [No,Yes]
1.5.1.6.1 1. year [No,Yes]
1.5.1.6.1.1 If clinically indicated [No,Yes]
1.5.1.6.1.2 Routinely [No,Yes]
1.5.1.6.1.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.6.2 2. year [No,Yes]
1.5.1.6.2.1 If clinically indicated [No,Yes]
1.5.1.6.2.2 Routinely [No,Yes]
1.5.1.6.2.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.6.3 3. year [No,Yes]
1.5.1.6.3.1 If clinically indicated [No,Yes]
1.5.1.6.3.2 Routinely [No,Yes]
1.5.1.6.3.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.6.4 4. year [No,Yes]
1.5.1.6.4.1 If clinically indicated [No,Yes]
1.5.1.6.4.2 Routinely [No,Yes]
1.5.1.6.4.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.6.5 5. year [No,Yes]
1.5.1.6.5.1 If clinically indicated [No,Yes]
1.5.1.6.5.2 Routinely [No,Yes]
1.5.1.6.5.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.7 Pap smear [No,Yes]
1.5.1.7.1 1. year [No,Yes]
1.5.1.7.1.1 If clinically indicated [No,Yes]
1.5.1.7.1.2 Routinely [No,Yes]
1.5.1.7.1.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.7.2 2. year [No,Yes]
1.5.1.7.2.1 If clinically indicated [No,Yes]
1.5.1.7.2.2 Routinely [No,Yes]
1.5.1.7.2.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.7.3 3. year [No,Yes]
1.5.1.7.3.1 If clinically indicated [No,Yes]
1.5.1.7.3.2 Routinely [No,Yes]
1.5.1.7.3.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.7.4 4. year [No,Yes]
1.5.1.7.4.1 If clinically indicated [No,Yes]
1.5.1.7.4.2 Routinely [No,Yes]
1.5.1.7.4.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.7.5 5. year [No,Yes]
1.5.1.7.5.1 If clinically indicated [No,Yes]
1.5.1.7.5.2 Routinely [No,Yes]
1.5.1.7.5.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.8 Physical examination [No,Yes]
1.5.1.8.1 1. year [No,Yes]
1.5.1.8.1.1 If clinically indicated [No,Yes]
1.5.1.8.1.2 Routinely [No,Yes]
1.5.1.8.1.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.8.2 2. year [No,Yes]
1.5.1.8.2.1 If clinically indicated [No,Yes]
1.5.1.8.2.2 Routinely [No,Yes]
1.5.1.8.2.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.8.3 3. year [No,Yes]
1.5.1.8.3.1 If clinically indicated [No,Yes]
1.5.1.8.3.2 Routinely [No,Yes]
1.5.1.8.3.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.8.4 4. year [No,Yes]
1.5.1.8.4.1 If clinically indicated [No,Yes]
1.5.1.8.4.2 Routinely [No,Yes]
1.5.1.8.4.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.8.5 5. year [No,Yes]
1.5.1.8.5.1 If clinically indicated [No,Yes]
1.5.1.8.5.2 Routinely [No,Yes]
1.5.1.8.5.2.1 Frequency every [12 month,3 month,6 month]
1.5.1.9 Other regular tests/procedures [No,Yes]
1.5.1.9.1 Description
1.5.2 Late serious adverse events ≥ 2 CTCAE grading (associated with the treatment, since the 31st postoperative day)
1.5.2.1 1. adverse event [No,Yes]
1.5.2.1.1 Type [Blood,Gastrointestinal,Infections,Other,Renal,Respiratory,Skin,Surgical,Vascular]
1.5.2.1.2 Grade [2,3,4,5]
1.5.2.1.3 Date of 1st diagnosis (month/year)
1.5.2.2 2. adverse event [No,Yes]
1.5.2.2.1 Type [Blood,Gastrointestinal,Infections,Other,Renal,Respiratory,Skin,Surgical,Vascular]
1.5.2.2.2 Grade [2,3,4,5]
1.5.2.2.3 Date of 1st diagnosis (month/year)
1.5.2.3 3. adverse event [No,Yes]
1.5.2.3.1 Type [Blood,Gastrointestinal,Infections,Other,Renal,Respiratory,Skin,Surgical,Vascular]
1.5.2.3.2 Grade [2,3,4,5]
1.5.2.3.3 Date of 1st diagnosis (month/year)
1.5.2.4 4. adverse event [No,Yes]
1.5.2.4.1 Type [Blood,Gastrointestinal,Infections,Other,Renal,Respiratory,Skin,Surgical,Vascular]
1.5.2.4.2 Grade [2,3,4,5]
1.5.2.4.3 Date of 1st diagnosis (month/year)
1.5.2.5 5. adverse event [No,Yes]
1.5.2.5.1 Type [Blood,Gastrointestinal,Infections,Other,Renal,Respiratory,Skin,Surgical,Vascular]
1.5.2.5.2 Grade [2,3,4,5]
1.5.2.5.3 Date of 1st diagnosis (month/year)
1.5.3 Date of last FU visit (month/year)
1.5.4 Status at the time of the last FU visit [Alive with disease (AWD),Death,No evidence of disease (NED)]
1.5.5 Date of death (month/year)
1.5.6 Cause of death [Disease progression,Intercurrent disease,Other,Other cancer,Treatment complications]
1.6 Recurrence
1.6.1 Cancer recurred [No,Yes]
1.6.2 Recurrence date (month/year)
1.6.3 Site
1.6.3.1 Pelvis [No,Yes]
1.6.3.1.1 Central [No,Yes]
1.6.3.1.2 Lateral [No,Yes]
1.6.3.1.3 Preserved uterus involved [No,Yes]
1.6.3.2 Abdomen [No,Yes]
1.6.3.3 Thorax [No,Yes]
1.6.3.4 Other distant [No,Yes]
1.6.4 Symptoms at the time of diagnosis [No,Yes]
1.6.5 Recurrence was treated [No,Yes]
1.6.6 Treatment of recurrence
1.6.6.1 Chemotherapy [No,Yes]
1.6.6.2 Experimental [No,Yes]
1.6.6.3 Immunotherapy [No,Yes]
1.6.6.4 Radiochemotherapy [No,Yes]
1.6.6.5 Radiotherapy [No,Yes]
1.6.6.6 Secondary surgery [No,Yes]
1.6.6.7 Targeted [No,Yes]
1.6.6.8 Other [No,Yes]
1.6.6.8.1 Description
1.6.7 Treatment response
1.6.7.1 Response of the 1st recurrence [Complete remission,Partial remission/stable disease,Progression]
1.6.7.2 2nd recurrence [No,Yes]
1.6.7.2.1 Third line treatment
1.6.7.2.1.1 Chemotherapy [No,Yes]
1.6.7.2.1.2 Experimental [No,Yes]
1.6.7.2.1.3 Immunotherapy [No,Yes]
1.6.7.2.1.4 Radiochemotherapy [No,Yes]
1.6.7.2.1.5 Radiotherapy [No,Yes]
1.6.7.2.1.6 Surgery [No,Yes]
1.6.7.2.1.7 Targeted [No,Yes]
1.6.7.2.1.8 Other [No,Yes]
1.6.7.2.1.8.1 Description
1.6.7.2.1.9 None [No,Yes]
1.6.7.3 Third line treatment
1.6.7.3.1 Chemotherapy [No,Yes]
1.6.7.3.2 Experimental [No,Yes]
1.6.7.3.3 Immunotherapy [No,Yes]
1.6.7.3.4 Radiochemotherapy [No,Yes]
1.6.7.3.5 Radiotherapy [No,Yes]
1.6.7.3.6 Surgery [No,Yes]
1.6.7.3.7 Targeted [No,Yes]
1.6.7.3.8 Other [No,Yes]
1.6.7.3.8.1 Description
1.6.7.3.9 None [No,Yes]