Fertility saving study

Fertility saving study
- Inclusion critera
  - Cervical cancer (any histology, any stage from T1a1) [No,Yes]
  - Fertility sparing treatment (FST) with the aim to preserve uterus (any procedure, at least attempt) [No,Yes]
  - Information of the outcome available (follow-up available) [No,Yes]
- Patient's data
  - Date of birth (month/year)
  - Parity before diagnosis
  - Previous gynecological surgery before cervical cancer diagnosis [No,Yes]
    - Date of surgery (YYYY)
    - Type of surgery
- Diagnosis and diagnostic work-up
  - Date of first diagnosis of cervical cancer (month/year)
  - Diagnostic procedure
  - Histology
    - Histological type
    - Grade
    - LVSI
  - Pre-treatment work-up
    - CT scan [No,Yes]
    - Colposcopy [No,Yes]
    - Cystoscopy [No,Yes]
    - DW-MRI [No,Yes]
    - MRI [No,Yes]
    - PET-CT [No,Yes]
    - PET-MRI [No,Yes]
    - Rectoscopy or colonoscopy [No,Yes]
    - Ultrasound [No,Yes]
  - Pre-treatment clinical and radiological stage (TNM classification)
- Primary treatment
  - Neoadjuvant chemotherapy (before the FST procedure) [No,Yes]
    - No of cycles
  - Surgical treatment
    - Cervical procedure
      - Date of procedure (month/year)
      - Type of procedure
    - Repeated cervical procedure (after FST) [No,Yes]
      - Date of procedure (month/year)
      - Reason
      - Description of other reason
      - Type of procedure
    - Lymph node procedure
      - Sentinel lymph node biopsy [No,Yes]
        
        Date of procedure (month/year)
        
        Total number of sentinel nodes
        
        Detection
        
        Methods of mapping
        
        Blue dye [No,Yes]
        
        Indocyanin green [No,Yes]
        
        Technecium [No,Yes]
      - Pelvic lymphadenectomy [No,Yes]
        
        Date of procedure (month/year)
        
        Total number of pelvic nodes (including sentinel nodes if done)
      - Paraaortic lymphadenectomy [No,Yes]
        
        Date of procedure (month/year)
        
        Total number of paraaortic nodes
    - Cerclage placement
      - Date of cerclage (month/year)
      - Timing of placement
      - Type of cerclage
  - Adjuvant chemotherapy (after treatment procedure) [No,Yes]
    - No of cycles
  - Definitive histology (after surgical treatment procedure)
    - Size of the tumor
      - horizontal spread / horizontal (AP)
      - stomal invasion / vertical (CC)
      - latero-lateral (LL)
    - Size of the cone or trachelectomy specimen
      - N/A [No,Yes]
      - Lenght (the distance from the external margin to the proximal/internal margin)
      - Thickness (the distance from the stromal margin to the surface of specimen)
    - Lymph nodes - histology
      - Only sentinel node(s)
      - Other pelvic (and paraaortic) nodes (if sentinel node biopsy was performed)
      - Only pelvic (and paraaortic) nodes (if sentinel node biopsy was not performed)
- Follow-up & recurrence
  - Oncological treatment (hysterectomy, radiotherapy, chemotherapy) during the follow-up period was given
  - Oncological treatment (hysterectomy, radiotherapy, chemotherapy) during the follow-up period
    - Date of treatment (month/year)
    - Reason
      - Abnormal Pap smear [No,Yes]
      - Cervical cancer recurrence [No,Yes]
      - Cervical stenosis/hematometra [No,Yes]
      - Doctor's decision (no disease suspected) [No,Yes]
      - HPV positivity [No,Yes]
      - Other [No,Yes]
      - Patient's decision (no disease suspected) [No,Yes]
      - Pre-cancer-recurrence (any proven LSIL, HSIL or AIS) [No,Yes]
      - Second cancer (endometrial, ovarian etc.) [No,Yes]
    - Type of treatment
      - Chemotherapy [No,Yes]
      - Hysterectomy [No,Yes]
      - Radiotherapy [No,Yes]
  - Follow-up procedure
    - Biopsy [No,Yes]
      - 1. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 2. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 3. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 4. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 5. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
    - CT [No,Yes]
      - 1. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 2. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 3. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 4. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 5. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
    - Colposcopy [No,Yes]
      - 1. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 2. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 3. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 4. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 5. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
    - HPV test [No,Yes]
      - 1. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 2. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 3. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 4. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 5. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
    - MRI [No,Yes]
      - 1. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 2. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 3. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 4. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 5. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
    - Others [No,Yes]
      - Procedures description
    - PET-CT [No,Yes]
      - 1. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 2. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 3. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 4. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 5. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
    - Pap smear [No,Yes]
      - 1. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 2. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 3. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 4. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 5. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
    - Physical examination [No,Yes]
      - 1. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 2. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 3. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 4. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 5. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
    - US [No,Yes]
      - 1. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 2. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 3. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 4. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
      - 5. year [No,Yes]
        
        If clinically indicated [No,Yes]
        
        Routinely [No,Yes]
        
        Frequency every
  - Date of last follow-up (month/year)
  - Pregnancy after primary treatment
    - Attempt to concieve [No,Yes]
      - More than 6 months [No,Yes]
      - Way of conception
        
        IVF program [No,Yes]
        
        Natural [No,Yes]
    - Pregnancy after treatment
      - Number of pregnancies
      - Number of abortions
      - Number of deliveries
    - Profylactic management during pregnancy [No,Yes]
      - Antibiotic treatment [No,Yes]
      - None [No,Yes]
      - Other [No,Yes]
        
        Description of the profylactic procedure
      - Preventive hospitalisation [No,Yes]
      - Profylactic cerclage during pregnancy [No,Yes]
      - Profylactic tocolytic therapy [No,Yes]
      - Progesterone administration [No,Yes]
      - Regular US cervicometry [No,Yes]
    - Delivery (complete repeatedly for each delivery) [No,Yes]
      - 1. delivery [No,Yes]
        
        Method of delivery
        
        Date of delivery (month/year)
      - 2. delivery [No,Yes]
        
        Method of delivery
        
        Date of delivery (month/year)
      - 3. delivery [No,Yes]
        
        Method of delivery
        
        Date of delivery (month/year)
      - 4. delivery [No,Yes]
        
        Method of delivery
        
        Date of delivery (month/year)
      - 5. delivery [No,Yes]
        
        Method of delivery
        
        Date of delivery (month/year)
  - Recurrence
    - Pre-cancer recurrence during the follow-up [No,Yes]
      - Pre-cancer histotype
    - Cancer recurrence [No,Yes]
      - Disease free interval (DFI)
      - Location
        
        Cervix [No,Yes]
        
        Distant - others [No,Yes]
        
        Description
        
        Distant abdomen [No,Yes]
        
        Distant thorax [No,Yes]
        
        Paraaortic lymph nodes [No,Yes]
        
        Parametrium [No,Yes]
        
        Pelvic lymph nodes [No,Yes]
        
        Pelvis - others [No,Yes]
        
        Description
        
        Vagina [No,Yes]
      - Symptoms of recurrence [No,Yes]
        
        Description
    - Main (or first) method(s) of recurrence detection
      - Biopsy [No,Yes]
      - CT [No,Yes]
      - Clinical symptoms [No,Yes]
      - Colposcopy [No,Yes]
      - Cytology [No,Yes]
      - Gynecological examination [No,Yes]
      - HPV test [No,Yes]
      - MRI [No,Yes]
      - Others [No,Yes]
        
        Description of procedures
      - PET-CT [No,Yes]
      - Physical examination [No,Yes]
      - US [No,Yes]
  - Current status
  - Date of death (month/year)
  - Cause of death