Fertility saving study

• + - Inclusion critera
  • Cervical cancer (any histology, any stage from T1a1) [No,Yes]
  • Fertility sparing treatment (FST) with the aim to preserve uterus (any procedure, at least attempt) [No,Yes]
  • Information of the outcome available (follow-up available) [No,Yes]
• + - Patient's data
  • Date of birth (month/year)
  • Parity before diagnosis
  • + - Previous gynecological surgery before cervical cancer diagnosis [No,Yes]
    • Date of surgery (YYYY)
    • Type of surgery
• + - Diagnosis and diagnostic work-up
  • Date of first diagnosis of cervical cancer (month/year)
  • Diagnostic procedure
  • + - Histology
    • Histological type
    • Grade
    • LVSI
  • + - Pre-treatment work-up
    • CT scan [No,Yes]
    • Colposcopy [No,Yes]
    • Cystoscopy [No,Yes]
    • DW-MRI [No,Yes]
    • MRI [No,Yes]
    • PET-CT [No,Yes]
    • PET-MRI [No,Yes]
    • Rectoscopy or colonoscopy [No,Yes]
    • Ultrasound [No,Yes]
  • Pre-treatment clinical and radiological stage (TNM classification)
• + - Primary treatment
  • + - Neoadjuvant chemotherapy (before the FST procedure) [No,Yes]
    • No of cycles
  • + - Surgical treatment
    • + - Cervical procedure
      • Date of procedure (month/year)
      • Type of procedure
    • + - Repeated cervical procedure (after FST) [No,Yes]
      • Date of procedure (month/year)
      • Reason
      • Description of other reason
      • Type of procedure
    • + - Lymph node procedure
      • + - Sentinel lymph node biopsy [No,Yes]
        • Date of procedure (month/year)
        • Total number of sentinel nodes
        • Detection
        • + - Methods of mapping
          • Blue dye [No,Yes]
          • Indocyanin green [No,Yes]
          • Technecium [No,Yes]
      • + - Pelvic lymphadenectomy [No,Yes]
        • Date of procedure (month/year)
        • Total number of pelvic nodes (including sentinel nodes if done)
      • + - Paraaortic lymphadenectomy [No,Yes]
        • Date of procedure (month/year)
        • Total number of paraaortic nodes
    • + - Cerclage placement
      • Date of cerclage (month/year)
      • Timing of placement
      • Type of cerclage
  • + - Adjuvant chemotherapy (after treatment procedure) [No,Yes]
    • No of cycles
  • + - Definitive histology (after surgical treatment procedure)
    • + - Size of the tumor
      • horizontal spread / horizontal (AP)
      • stomal invasion / vertical (CC)
      • latero-lateral (LL)
    • + - Size of the cone or trachelectomy specimen
      • N/A [No,Yes]
      • Lenght (the distance from the external margin to the proximal/internal margin)
      • Thickness (the distance from the stromal margin to the surface of specimen)
    • + - Lymph nodes - histology
      • Only sentinel node(s)
      • Other pelvic (and paraaortic) nodes (if sentinel node biopsy was performed)
      • Only pelvic (and paraaortic) nodes (if sentinel node biopsy was not performed)
• + - Follow-up & recurrence
  • Oncological treatment (hysterectomy, radiotherapy, chemotherapy) during the follow-up period was given
  • + - Oncological treatment (hysterectomy, radiotherapy, chemotherapy) during the follow-up period
    • Date of treatment (month/year)
    • + - Reason
      • Abnormal Pap smear [No,Yes]
      • Cervical cancer recurrence [No,Yes]
      • Cervical stenosis/hematometra [No,Yes]
      • Doctor's decision (no disease suspected) [No,Yes]
      • HPV positivity [No,Yes]
      • Other [No,Yes]
      • Patient's decision (no disease suspected) [No,Yes]
      • Pre-cancer-recurrence (any proven LSIL, HSIL or AIS) [No,Yes]
      • Second cancer (endometrial, ovarian etc.) [No,Yes]
    • + - Type of treatment
      • Chemotherapy [No,Yes]
      • Hysterectomy [No,Yes]
      • Radiotherapy [No,Yes]
  • + - Follow-up procedure
    • + - Biopsy [No,Yes]
      • + - 1. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 2. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 3. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 4. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 5. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
    • + - CT [No,Yes]
      • + - 1. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 2. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 3. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 4. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 5. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
    • + - Colposcopy [No,Yes]
      • + - 1. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 2. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 3. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 4. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 5. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
    • + - HPV test [No,Yes]
      • + - 1. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 2. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 3. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 4. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 5. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
    • + - MRI [No,Yes]
      • + - 1. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 2. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 3. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 4. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 5. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
    • + - Others [No,Yes]
      • Procedures description
    • + - PET-CT [No,Yes]
      • + - 1. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 2. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 3. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 4. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 5. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
    • + - Pap smear [No,Yes]
      • + - 1. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 2. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 3. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 4. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 5. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
    • + - Physical examination [No,Yes]
      • + - 1. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 2. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 3. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 4. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 5. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
    • + - US [No,Yes]
      • + - 1. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 2. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 3. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 4. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
      • + - 5. year [No,Yes]
        • If clinically indicated [No,Yes]
        • + - Routinely [No,Yes]
          • Frequency every
  • Date of last follow-up (month/year)
  • + - Pregnancy after primary treatment
    • + - Attempt to concieve [No,Yes]
      • More than 6 months [No,Yes]
      • + - Way of conception
        • IVF program [No,Yes]
        • Natural [No,Yes]
    • + - Pregnancy after treatment
      • Number of pregnancies
      • Number of abortions
      • Number of deliveries
    • + - Profylactic management during pregnancy [No,Yes]
      • Antibiotic treatment [No,Yes]
      • None [No,Yes]
      • + - Other [No,Yes]
        • Description of the profylactic procedure
      • Preventive hospitalisation [No,Yes]
      • Profylactic cerclage during pregnancy [No,Yes]
      • Profylactic tocolytic therapy [No,Yes]
      • Progesterone administration [No,Yes]
      • Regular US cervicometry [No,Yes]
    • + - Delivery (complete repeatedly for each delivery) [No,Yes]
      • + - 1. delivery [No,Yes]
        • Method of delivery
        • Date of delivery (month/year)
      • + - 2. delivery [No,Yes]
        • Method of delivery
        • Date of delivery (month/year)
      • + - 3. delivery [No,Yes]
        • Method of delivery
        • Date of delivery (month/year)
      • + - 4. delivery [No,Yes]
        • Method of delivery
        • Date of delivery (month/year)
      • + - 5. delivery [No,Yes]
        • Method of delivery
        • Date of delivery (month/year)
  • + - Recurrence
    • + - Pre-cancer recurrence during the follow-up [No,Yes]
      • Pre-cancer histotype
    • + - Cancer recurrence [No,Yes]
      • Disease free interval (DFI)
      • + - Location
        • Cervix [No,Yes]
        • + - Distant - others [No,Yes]
          • Description
        • Distant abdomen [No,Yes]
        • Distant thorax [No,Yes]
        • Paraaortic lymph nodes [No,Yes]
        • Parametrium [No,Yes]
        • Pelvic lymph nodes [No,Yes]
        • + - Pelvis - others [No,Yes]
          • Description
        • Vagina [No,Yes]
      • + - Symptoms of recurrence [No,Yes]
        • Description
    • + - Main (or first) method(s) of recurrence detection
      • Biopsy [No,Yes]
      • CT [No,Yes]
      • Clinical symptoms [No,Yes]
      • Colposcopy [No,Yes]
      • Cytology [No,Yes]
      • Gynecological examination [No,Yes]
      • HPV test [No,Yes]
      • MRI [No,Yes]
      • + - Others [No,Yes]
        • Description of procedures
      • PET-CT [No,Yes]
      • Physical examination [No,Yes]
      • US [No,Yes]
  • Current status
  • Date of death (month/year)
  • Cause of death