1 Fertility saving study
1.1 Inclusion critera
1.1.1 Cervical cancer (any histology, any stage from T1a1) [No,Yes]
1.1.2 Fertility sparing treatment (FST) with the aim to preserve uterus (any procedure, at least attempt) [No,Yes]
1.1.3 Information of the outcome available (follow-up available) [No,Yes]
1.2 Patient's data
1.2.1 Date of birth (month/year)
1.2.2 Parity before diagnosis
1.2.3 Previous gynecological surgery before cervical cancer diagnosis [No,Yes]
1.2.3.1 Date of surgery (YYYY)
1.2.3.2 Type of surgery
1.3 Diagnosis and diagnostic work-up
1.3.1 Date of first diagnosis of cervical cancer (month/year)
1.3.2 Diagnostic procedure
1.3.3 Histology
1.3.3.1 Histological type
1.3.3.2 Grade
1.3.3.3 LVSI
1.3.4 Pre-treatment work-up
1.3.4.1 CT scan [No,Yes]
1.3.4.2 Colposcopy [No,Yes]
1.3.4.3 Cystoscopy [No,Yes]
1.3.4.4 DW-MRI [No,Yes]
1.3.4.5 MRI [No,Yes]
1.3.4.6 PET-CT [No,Yes]
1.3.4.7 PET-MRI [No,Yes]
1.3.4.8 Rectoscopy or colonoscopy [No,Yes]
1.3.4.9 Ultrasound [No,Yes]
1.3.5 Pre-treatment clinical and radiological stage (TNM classification)
1.4 Primary treatment
1.4.1 Neoadjuvant chemotherapy (before the FST procedure) [No,Yes]
1.4.1.1 No of cycles
1.4.2 Surgical treatment
1.4.2.1 Cervical procedure
1.4.2.1.1 Date of procedure (month/year)
1.4.2.1.2 Type of procedure
1.4.2.2 Repeated cervical procedure (after FST) [No,Yes]
1.4.2.2.1 Date of procedure (month/year)
1.4.2.2.2 Reason
1.4.2.2.3 Description of other reason
1.4.2.2.4 Type of procedure
1.4.2.3 Lymph node procedure
1.4.2.3.1 Sentinel lymph node biopsy [No,Yes]
1.4.2.3.1.1 Date of procedure (month/year)
1.4.2.3.1.2 Total number of sentinel nodes
1.4.2.3.1.3 Detection
1.4.2.3.1.4 Methods of mapping
1.4.2.3.1.4.1 Blue dye [No,Yes]
1.4.2.3.1.4.2 Indocyanin green [No,Yes]
1.4.2.3.1.4.3 Technecium [No,Yes]
1.4.2.3.2 Pelvic lymphadenectomy [No,Yes]
1.4.2.3.2.1 Date of procedure (month/year)
1.4.2.3.2.2 Total number of pelvic nodes (including sentinel nodes if done)
1.4.2.3.3 Paraaortic lymphadenectomy [No,Yes]
1.4.2.3.3.1 Date of procedure (month/year)
1.4.2.3.3.2 Total number of paraaortic nodes
1.4.2.4 Cerclage placement
1.4.2.4.1 Date of cerclage (month/year)
1.4.2.4.2 Timing of placement
1.4.2.4.3 Type of cerclage
1.4.3 Adjuvant chemotherapy (after treatment procedure) [No,Yes]
1.4.3.1 No of cycles
1.4.4 Definitive histology (after surgical treatment procedure)
1.4.4.1 Size of the tumor
1.4.4.1.1 horizontal spread / horizontal (AP)
1.4.4.1.2 stomal invasion / vertical (CC)
1.4.4.1.3 latero-lateral (LL)
1.4.4.2 Size of the cone or trachelectomy specimen
1.4.4.2.1 N/A [No,Yes]
1.4.4.2.2 Lenght (the distance from the external margin to the proximal/internal margin)
1.4.4.2.3 Thickness (the distance from the stromal margin to the surface of specimen)
1.4.4.3 Lymph nodes - histology
1.4.4.3.1 Only sentinel node(s)
1.4.4.3.2 Other pelvic (and paraaortic) nodes (if sentinel node biopsy was performed)
1.4.4.3.3 Only pelvic (and paraaortic) nodes (if sentinel node biopsy was not performed)
1.5 Follow-up & recurrence
1.5.1 Oncological treatment (hysterectomy, radiotherapy, chemotherapy) during the follow-up period was given
1.5.2 Oncological treatment (hysterectomy, radiotherapy, chemotherapy) during the follow-up period
1.5.2.1 Date of treatment (month/year)
1.5.2.2 Reason
1.5.2.2.1 Abnormal Pap smear [No,Yes]
1.5.2.2.2 Cervical cancer recurrence [No,Yes]
1.5.2.2.3 Cervical stenosis/hematometra [No,Yes]
1.5.2.2.4 Doctor's decision (no disease suspected) [No,Yes]
1.5.2.2.5 HPV positivity [No,Yes]
1.5.2.2.6 Other [No,Yes]
1.5.2.2.7 Patient's decision (no disease suspected) [No,Yes]
1.5.2.2.8 Pre-cancer-recurrence (any proven LSIL, HSIL or AIS) [No,Yes]
1.5.2.2.9 Second cancer (endometrial, ovarian etc.) [No,Yes]
1.5.2.3 Type of treatment
1.5.2.3.1 Chemotherapy [No,Yes]
1.5.2.3.2 Hysterectomy [No,Yes]
1.5.2.3.3 Radiotherapy [No,Yes]
1.5.3 Follow-up procedure
1.5.3.1 Biopsy [No,Yes]
1.5.3.1.1 1. year [No,Yes]
1.5.3.1.1.1 If clinically indicated [No,Yes]
1.5.3.1.1.2 Routinely [No,Yes]
1.5.3.1.1.2.1 Frequency every
1.5.3.1.2 2. year [No,Yes]
1.5.3.1.2.1 If clinically indicated [No,Yes]
1.5.3.1.2.2 Routinely [No,Yes]
1.5.3.1.2.2.1 Frequency every
1.5.3.1.3 3. year [No,Yes]
1.5.3.1.3.1 If clinically indicated [No,Yes]
1.5.3.1.3.2 Routinely [No,Yes]
1.5.3.1.3.2.1 Frequency every
1.5.3.1.4 4. year [No,Yes]
1.5.3.1.4.1 If clinically indicated [No,Yes]
1.5.3.1.4.2 Routinely [No,Yes]
1.5.3.1.4.2.1 Frequency every
1.5.3.1.5 5. year [No,Yes]
1.5.3.1.5.1 If clinically indicated [No,Yes]
1.5.3.1.5.2 Routinely [No,Yes]
1.5.3.1.5.2.1 Frequency every
1.5.3.2 CT [No,Yes]
1.5.3.2.1 1. year [No,Yes]
1.5.3.2.1.1 If clinically indicated [No,Yes]
1.5.3.2.1.2 Routinely [No,Yes]
1.5.3.2.1.2.1 Frequency every
1.5.3.2.2 2. year [No,Yes]
1.5.3.2.2.1 If clinically indicated [No,Yes]
1.5.3.2.2.2 Routinely [No,Yes]
1.5.3.2.2.2.1 Frequency every
1.5.3.2.3 3. year [No,Yes]
1.5.3.2.3.1 If clinically indicated [No,Yes]
1.5.3.2.3.2 Routinely [No,Yes]
1.5.3.2.3.2.1 Frequency every
1.5.3.2.4 4. year [No,Yes]
1.5.3.2.4.1 If clinically indicated [No,Yes]
1.5.3.2.4.2 Routinely [No,Yes]
1.5.3.2.4.2.1 Frequency every
1.5.3.2.5 5. year [No,Yes]
1.5.3.2.5.1 If clinically indicated [No,Yes]
1.5.3.2.5.2 Routinely [No,Yes]
1.5.3.2.5.2.1 Frequency every
1.5.3.3 Colposcopy [No,Yes]
1.5.3.3.1 1. year [No,Yes]
1.5.3.3.1.1 If clinically indicated [No,Yes]
1.5.3.3.1.2 Routinely [No,Yes]
1.5.3.3.1.2.1 Frequency every
1.5.3.3.2 2. year [No,Yes]
1.5.3.3.2.1 If clinically indicated [No,Yes]
1.5.3.3.2.2 Routinely [No,Yes]
1.5.3.3.2.2.1 Frequency every
1.5.3.3.3 3. year [No,Yes]
1.5.3.3.3.1 If clinically indicated [No,Yes]
1.5.3.3.3.2 Routinely [No,Yes]
1.5.3.3.3.2.1 Frequency every
1.5.3.3.4 4. year [No,Yes]
1.5.3.3.4.1 If clinically indicated [No,Yes]
1.5.3.3.4.2 Routinely [No,Yes]
1.5.3.3.4.2.1 Frequency every
1.5.3.3.5 5. year [No,Yes]
1.5.3.3.5.1 If clinically indicated [No,Yes]
1.5.3.3.5.2 Routinely [No,Yes]
1.5.3.3.5.2.1 Frequency every
1.5.3.4 HPV test [No,Yes]
1.5.3.4.1 1. year [No,Yes]
1.5.3.4.1.1 If clinically indicated [No,Yes]
1.5.3.4.1.2 Routinely [No,Yes]
1.5.3.4.1.2.1 Frequency every
1.5.3.4.2 2. year [No,Yes]
1.5.3.4.2.1 If clinically indicated [No,Yes]
1.5.3.4.2.2 Routinely [No,Yes]
1.5.3.4.2.2.1 Frequency every
1.5.3.4.3 3. year [No,Yes]
1.5.3.4.3.1 If clinically indicated [No,Yes]
1.5.3.4.3.2 Routinely [No,Yes]
1.5.3.4.3.2.1 Frequency every
1.5.3.4.4 4. year [No,Yes]
1.5.3.4.4.1 If clinically indicated [No,Yes]
1.5.3.4.4.2 Routinely [No,Yes]
1.5.3.4.4.2.1 Frequency every
1.5.3.4.5 5. year [No,Yes]
1.5.3.4.5.1 If clinically indicated [No,Yes]
1.5.3.4.5.2 Routinely [No,Yes]
1.5.3.4.5.2.1 Frequency every
1.5.3.5 MRI [No,Yes]
1.5.3.5.1 1. year [No,Yes]
1.5.3.5.1.1 If clinically indicated [No,Yes]
1.5.3.5.1.2 Routinely [No,Yes]
1.5.3.5.1.2.1 Frequency every
1.5.3.5.2 2. year [No,Yes]
1.5.3.5.2.1 If clinically indicated [No,Yes]
1.5.3.5.2.2 Routinely [No,Yes]
1.5.3.5.2.2.1 Frequency every
1.5.3.5.3 3. year [No,Yes]
1.5.3.5.3.1 If clinically indicated [No,Yes]
1.5.3.5.3.2 Routinely [No,Yes]
1.5.3.5.3.2.1 Frequency every
1.5.3.5.4 4. year [No,Yes]
1.5.3.5.4.1 If clinically indicated [No,Yes]
1.5.3.5.4.2 Routinely [No,Yes]
1.5.3.5.4.2.1 Frequency every
1.5.3.5.5 5. year [No,Yes]
1.5.3.5.5.1 If clinically indicated [No,Yes]
1.5.3.5.5.2 Routinely [No,Yes]
1.5.3.5.5.2.1 Frequency every
1.5.3.6 Others [No,Yes]
1.5.3.6.1 Procedures description
1.5.3.7 PET-CT [No,Yes]
1.5.3.7.1 1. year [No,Yes]
1.5.3.7.1.1 If clinically indicated [No,Yes]
1.5.3.7.1.2 Routinely [No,Yes]
1.5.3.7.1.2.1 Frequency every
1.5.3.7.2 2. year [No,Yes]
1.5.3.7.2.1 If clinically indicated [No,Yes]
1.5.3.7.2.2 Routinely [No,Yes]
1.5.3.7.2.2.1 Frequency every
1.5.3.7.3 3. year [No,Yes]
1.5.3.7.3.1 If clinically indicated [No,Yes]
1.5.3.7.3.2 Routinely [No,Yes]
1.5.3.7.3.2.1 Frequency every
1.5.3.7.4 4. year [No,Yes]
1.5.3.7.4.1 If clinically indicated [No,Yes]
1.5.3.7.4.2 Routinely [No,Yes]
1.5.3.7.4.2.1 Frequency every
1.5.3.7.5 5. year [No,Yes]
1.5.3.7.5.1 If clinically indicated [No,Yes]
1.5.3.7.5.2 Routinely [No,Yes]
1.5.3.7.5.2.1 Frequency every
1.5.3.8 Pap smear [No,Yes]
1.5.3.8.1 1. year [No,Yes]
1.5.3.8.1.1 If clinically indicated [No,Yes]
1.5.3.8.1.2 Routinely [No,Yes]
1.5.3.8.1.2.1 Frequency every
1.5.3.8.2 2. year [No,Yes]
1.5.3.8.2.1 If clinically indicated [No,Yes]
1.5.3.8.2.2 Routinely [No,Yes]
1.5.3.8.2.2.1 Frequency every
1.5.3.8.3 3. year [No,Yes]
1.5.3.8.3.1 If clinically indicated [No,Yes]
1.5.3.8.3.2 Routinely [No,Yes]
1.5.3.8.3.2.1 Frequency every
1.5.3.8.4 4. year [No,Yes]
1.5.3.8.4.1 If clinically indicated [No,Yes]
1.5.3.8.4.2 Routinely [No,Yes]
1.5.3.8.4.2.1 Frequency every
1.5.3.8.5 5. year [No,Yes]
1.5.3.8.5.1 If clinically indicated [No,Yes]
1.5.3.8.5.2 Routinely [No,Yes]
1.5.3.8.5.2.1 Frequency every
1.5.3.9 Physical examination [No,Yes]
1.5.3.9.1 1. year [No,Yes]
1.5.3.9.1.1 If clinically indicated [No,Yes]
1.5.3.9.1.2 Routinely [No,Yes]
1.5.3.9.1.2.1 Frequency every
1.5.3.9.2 2. year [No,Yes]
1.5.3.9.2.1 If clinically indicated [No,Yes]
1.5.3.9.2.2 Routinely [No,Yes]
1.5.3.9.2.2.1 Frequency every
1.5.3.9.3 3. year [No,Yes]
1.5.3.9.3.1 If clinically indicated [No,Yes]
1.5.3.9.3.2 Routinely [No,Yes]
1.5.3.9.3.2.1 Frequency every
1.5.3.9.4 4. year [No,Yes]
1.5.3.9.4.1 If clinically indicated [No,Yes]
1.5.3.9.4.2 Routinely [No,Yes]
1.5.3.9.4.2.1 Frequency every
1.5.3.9.5 5. year [No,Yes]
1.5.3.9.5.1 If clinically indicated [No,Yes]
1.5.3.9.5.2 Routinely [No,Yes]
1.5.3.9.5.2.1 Frequency every
1.5.3.10 US [No,Yes]
1.5.3.10.1 1. year [No,Yes]
1.5.3.10.1.1 If clinically indicated [No,Yes]
1.5.3.10.1.2 Routinely [No,Yes]
1.5.3.10.1.2.1 Frequency every
1.5.3.10.2 2. year [No,Yes]
1.5.3.10.2.1 If clinically indicated [No,Yes]
1.5.3.10.2.2 Routinely [No,Yes]
1.5.3.10.2.2.1 Frequency every
1.5.3.10.3 3. year [No,Yes]
1.5.3.10.3.1 If clinically indicated [No,Yes]
1.5.3.10.3.2 Routinely [No,Yes]
1.5.3.10.3.2.1 Frequency every
1.5.3.10.4 4. year [No,Yes]
1.5.3.10.4.1 If clinically indicated [No,Yes]
1.5.3.10.4.2 Routinely [No,Yes]
1.5.3.10.4.2.1 Frequency every
1.5.3.10.5 5. year [No,Yes]
1.5.3.10.5.1 If clinically indicated [No,Yes]
1.5.3.10.5.2 Routinely [No,Yes]
1.5.3.10.5.2.1 Frequency every
1.5.4 Date of last follow-up (month/year)
1.5.5 Pregnancy after primary treatment
1.5.5.1 Attempt to concieve [No,Yes]
1.5.5.1.1 More than 6 months [No,Yes]
1.5.5.1.2 Way of conception
1.5.5.1.2.1 IVF program [No,Yes]
1.5.5.1.2.2 Natural [No,Yes]
1.5.5.2 Pregnancy after treatment
1.5.5.2.1 Number of pregnancies
1.5.5.2.2 Number of abortions
1.5.5.2.3 Number of deliveries
1.5.5.3 Profylactic management during pregnancy [No,Yes]
1.5.5.3.1 Antibiotic treatment [No,Yes]
1.5.5.3.2 None [No,Yes]
1.5.5.3.3 Other [No,Yes]
1.5.5.3.3.1 Description of the profylactic procedure
1.5.5.3.4 Preventive hospitalisation [No,Yes]
1.5.5.3.5 Profylactic cerclage during pregnancy [No,Yes]
1.5.5.3.6 Profylactic tocolytic therapy [No,Yes]
1.5.5.3.7 Progesterone administration [No,Yes]
1.5.5.3.8 Regular US cervicometry [No,Yes]
1.5.5.4 Delivery (complete repeatedly for each delivery) [No,Yes]
1.5.5.4.1 1. delivery [No,Yes]
1.5.5.4.1.1 Method of delivery
1.5.5.4.1.2 Date of delivery (month/year)
1.5.5.4.2 2. delivery [No,Yes]
1.5.5.4.2.1 Method of delivery
1.5.5.4.2.2 Date of delivery (month/year)
1.5.5.4.3 3. delivery [No,Yes]
1.5.5.4.3.1 Method of delivery
1.5.5.4.3.2 Date of delivery (month/year)
1.5.5.4.4 4. delivery [No,Yes]
1.5.5.4.4.1 Method of delivery
1.5.5.4.4.2 Date of delivery (month/year)
1.5.5.4.5 5. delivery [No,Yes]
1.5.5.4.5.1 Method of delivery
1.5.5.4.5.2 Date of delivery (month/year)
1.5.6 Recurrence
1.5.6.1 Pre-cancer recurrence during the follow-up [No,Yes]
1.5.6.1.1 Pre-cancer histotype
1.5.6.2 Cancer recurrence [No,Yes]
1.5.6.2.1 Disease free interval (DFI)
1.5.6.2.2 Location
1.5.6.2.2.1 Cervix [No,Yes]
1.5.6.2.2.2 Distant - others [No,Yes]
1.5.6.2.2.2.1 Description
1.5.6.2.2.3 Distant abdomen [No,Yes]
1.5.6.2.2.4 Distant thorax [No,Yes]
1.5.6.2.2.5 Paraaortic lymph nodes [No,Yes]
1.5.6.2.2.6 Parametrium [No,Yes]
1.5.6.2.2.7 Pelvic lymph nodes [No,Yes]
1.5.6.2.2.8 Pelvis - others [No,Yes]
1.5.6.2.2.8.1 Description
1.5.6.2.2.9 Vagina [No,Yes]
1.5.6.2.3 Symptoms of recurrence [No,Yes]
1.5.6.2.3.1 Description
1.5.6.3 Main (or first) method(s) of recurrence detection
1.5.6.3.1 Biopsy [No,Yes]
1.5.6.3.2 CT [No,Yes]
1.5.6.3.3 Clinical symptoms [No,Yes]
1.5.6.3.4 Colposcopy [No,Yes]
1.5.6.3.5 Cytology [No,Yes]
1.5.6.3.6 Gynecological examination [No,Yes]
1.5.6.3.7 HPV test [No,Yes]
1.5.6.3.8 MRI [No,Yes]
1.5.6.3.9 Others [No,Yes]
1.5.6.3.9.1 Description of procedures
1.5.6.3.10 PET-CT [No,Yes]
1.5.6.3.11 Physical examination [No,Yes]
1.5.6.3.12 US [No,Yes]
1.5.7 Current status
1.5.8 Date of death (month/year)
1.5.9 Cause of death