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Fertility saving study

Inclusion critera

Cervical cancer (any histology, any stage from T1a1) [No,Yes]

Fertility sparing treatment (FST) with the aim to preserve uterus (any procedure, at least attempt) [No,Yes]

Information of the outcome available (follow-up available) [No,Yes]

Patient's data

```
Date of birth (month/year)
```

```
Parity before diagnosis
```

Previous gynecological surgery before cervical cancer diagnosis [No,Yes]

```
Date of surgery (YYYY)
```

```
Type of surgery
```

Diagnosis and diagnostic work-up

Date of first diagnosis of cervical cancer (month/year)

```
Diagnostic procedure
```

```
Histology
```
- ```
Histological type
```
- ```
Grade
```
- ```
LVSI
```

Pre-treatment work-up

```
CT scan [No,Yes]
```

```
Colposcopy [No,Yes]
```

```
Cystoscopy [No,Yes]
```

```
DW-MRI [No,Yes]
```

```
MRI [No,Yes]
```

```
PET-CT [No,Yes]
```

```
PET-MRI [No,Yes]
```

```
Rectoscopy or colonoscopy [No,Yes]
```

```
Ultrasound [No,Yes]
```

Pre-treatment clinical and radiological stage (TNM classification)

Primary treatment

Neoadjuvant chemotherapy (before the FST procedure) [No,Yes]

```
No of cycles
```

Surgical treatment

Cervical procedure

```
Date of procedure (month/year)
```

```
Type of procedure
```

Repeated cervical procedure (after FST) [No,Yes]

```
Date of procedure (month/year)
```

```
Reason
```

```
Description of other reason
```

```
Type of procedure
```

Lymph node procedure

Sentinel lymph node biopsy [No,Yes]

```
Date of procedure (month/year)
```

```
Total number of sentinel nodes
```

```
Detection
```

Methods of mapping

```
Blue dye [No,Yes]
```

```
Indocyanin green [No,Yes]
```

```
Technecium [No,Yes]
```

Pelvic lymphadenectomy [No,Yes]

```
Date of procedure (month/year)
```

Total number of pelvic nodes (including sentinel nodes if done)

Paraaortic lymphadenectomy [No,Yes]

```
Date of procedure (month/year)
```

```
Total number of paraaortic nodes
```

Cerclage placement

```
Date of cerclage (month/year)
```

```
Timing of placement
```

```
Type of cerclage
```

Adjuvant chemotherapy (after treatment procedure) [No,Yes]

```
No of cycles
```

Definitive histology (after surgical treatment procedure)

Size of the tumor

```
horizontal spread / horizontal (AP)
```

```
stomal invasion / vertical (CC)
```

```
latero-lateral (LL)
```

Size of the cone or trachelectomy specimen

```
N/A [No,Yes]
```

Lenght (the distance from the external margin to the proximal/internal margin)

Thickness (the distance from the stromal margin to the surface of specimen)

Lymph nodes - histology

```
Only sentinel node(s)
```

Other pelvic (and paraaortic) nodes (if sentinel node biopsy was performed)

Only pelvic (and paraaortic) nodes (if sentinel node biopsy was not performed)

Follow-up & recurrence

Oncological treatment (hysterectomy, radiotherapy, chemotherapy) during the follow-up period was given

Oncological treatment (hysterectomy, radiotherapy, chemotherapy) during the follow-up period

```
Date of treatment (month/year)
```

Reason

```
Abnormal Pap smear [No,Yes]
```

```
Cervical cancer recurrence [No,Yes]
```

```
Cervical stenosis/hematometra [No,Yes]
```

Doctor's decision (no disease suspected) [No,Yes]

```
HPV positivity [No,Yes]
```

```
Other [No,Yes]
```

Patient's decision (no disease suspected) [No,Yes]

Pre-cancer-recurrence (any proven LSIL, HSIL or AIS) [No,Yes]

Second cancer (endometrial, ovarian etc.) [No,Yes]

Type of treatment

```
Chemotherapy [No,Yes]
```

```
Hysterectomy [No,Yes]
```

```
Radiotherapy [No,Yes]
```

Follow-up procedure

Biopsy [No,Yes]

1. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

2. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

3. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

4. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

5. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

CT [No,Yes]

1. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

2. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

3. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

4. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

5. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

Colposcopy [No,Yes]

1. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

2. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

3. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

4. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

5. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

HPV test [No,Yes]

1. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

2. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

3. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

4. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

5. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

MRI [No,Yes]

1. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

2. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

3. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

4. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

5. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

```
Others [No,Yes]
```
- ```
Procedures description
```

PET-CT [No,Yes]

1. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

2. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

3. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

4. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

5. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

Pap smear [No,Yes]

1. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

2. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

3. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

4. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

5. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

Physical examination [No,Yes]

1. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

2. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

3. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

4. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

5. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

US [No,Yes]

1. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

2. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

3. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

4. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

5. year [No,Yes]

```
If clinically indicated [No,Yes]
```

```
Routinely [No,Yes]
```
- ```
Frequency every
```

```
Date of last follow-up (month/year)
```

Pregnancy after primary treatment

Attempt to concieve [No,Yes]

```
More than 6 months [No,Yes]
```

Way of conception

```
IVF program [No,Yes]
```

```
Natural [No,Yes]
```

Pregnancy after treatment

```
Number of pregnancies
```

```
Number of abortions
```

```
Number of deliveries
```

Profylactic management during pregnancy [No,Yes]

```
Antibiotic treatment [No,Yes]
```

```
None [No,Yes]
```

Other [No,Yes]

Description of the profylactic procedure

```
Preventive hospitalisation [No,Yes]
```

Profylactic cerclage during pregnancy [No,Yes]

```
Profylactic tocolytic therapy [No,Yes]
```

```
Progesterone administration [No,Yes]
```

```
Regular US cervicometry [No,Yes]
```

Delivery (complete repeatedly for each delivery) [No,Yes]

1. delivery [No,Yes]

```
Method of delivery
```

```
Date of delivery (month/year)
```

2. delivery [No,Yes]

```
Method of delivery
```

```
Date of delivery (month/year)
```

3. delivery [No,Yes]

```
Method of delivery
```

```
Date of delivery (month/year)
```

4. delivery [No,Yes]

```
Method of delivery
```

```
Date of delivery (month/year)
```

5. delivery [No,Yes]

```
Method of delivery
```

```
Date of delivery (month/year)
```

Recurrence

Pre-cancer recurrence during the follow-up [No,Yes]

```
Pre-cancer histotype
```

Cancer recurrence [No,Yes]

```
Disease free interval (DFI)
```

Location

```
Cervix [No,Yes]
```

```
Distant - others [No,Yes]
```
- ```
Description
```

```
Distant abdomen [No,Yes]
```

```
Distant thorax [No,Yes]
```

```
Paraaortic lymph nodes [No,Yes]
```

```
Parametrium [No,Yes]
```

```
Pelvic lymph nodes [No,Yes]
```

```
Pelvis - others [No,Yes]
```
- ```
Description
```

```
Vagina [No,Yes]
```

Symptoms of recurrence [No,Yes]

```
Description
```

Main (or first) method(s) of recurrence detection

```
Biopsy [No,Yes]
```

```
CT [No,Yes]
```

```
Clinical symptoms [No,Yes]
```

```
Colposcopy [No,Yes]
```

```
Cytology [No,Yes]
```

```
Gynecological examination [No,Yes]
```

```
HPV test [No,Yes]
```

```
MRI [No,Yes]
```

Others [No,Yes]

```
Description of procedures
```

```
PET-CT [No,Yes]
```

```
Physical examination [No,Yes]
```

```
US [No,Yes]
```

```
Current status
```

```
Date of death (month/year)
```

```
Cause of death
```

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