Fertility saving study
Fertility saving study
Inclusion critera
Cervical cancer (any histology, any stage from T1a1) [No,Yes]
Fertility sparing treatment (FST) with the aim to preserve uterus (any procedure, at least attempt) [No,Yes]
Information of the outcome available (follow-up available) [No,Yes]
Patient's data
Date of birth (month/year)
Parity before diagnosis
Previous gynecological surgery before cervical cancer diagnosis [No,Yes]
Date of surgery (YYYY)
Type of surgery
Diagnosis and diagnostic work-up
Date of first diagnosis of cervical cancer (month/year)
Diagnostic procedure
Histology
Histological type
Grade
LVSI
Pre-treatment work-up
CT scan [No,Yes]
Colposcopy [No,Yes]
Cystoscopy [No,Yes]
DW-MRI [No,Yes]
MRI [No,Yes]
PET-CT [No,Yes]
PET-MRI [No,Yes]
Rectoscopy or colonoscopy [No,Yes]
Ultrasound [No,Yes]
Pre-treatment clinical and radiological stage (TNM classification)
Primary treatment
Neoadjuvant chemotherapy (before the FST procedure) [No,Yes]
No of cycles
Surgical treatment
Cervical procedure
Date of procedure (month/year)
Type of procedure
Repeated cervical procedure (after FST) [No,Yes]
Date of procedure (month/year)
Reason
Description of other reason
Type of procedure
Lymph node procedure
Sentinel lymph node biopsy [No,Yes]
Date of procedure (month/year)
Total number of sentinel nodes
Detection
Methods of mapping
Blue dye [No,Yes]
Indocyanin green [No,Yes]
Technecium [No,Yes]
Pelvic lymphadenectomy [No,Yes]
Date of procedure (month/year)
Total number of pelvic nodes (including sentinel nodes if done)
Paraaortic lymphadenectomy [No,Yes]
Date of procedure (month/year)
Total number of paraaortic nodes
Cerclage placement
Date of cerclage (month/year)
Timing of placement
Type of cerclage
Adjuvant chemotherapy (after treatment procedure) [No,Yes]
No of cycles
Definitive histology (after surgical treatment procedure)
Size of the tumor
horizontal spread / horizontal (AP)
stomal invasion / vertical (CC)
latero-lateral (LL)
Size of the cone or trachelectomy specimen
N/A [No,Yes]
Lenght (the distance from the external margin to the proximal/internal margin)
Thickness (the distance from the stromal margin to the surface of specimen)
Lymph nodes - histology
Only sentinel node(s)
Other pelvic (and paraaortic) nodes (if sentinel node biopsy was performed)
Only pelvic (and paraaortic) nodes (if sentinel node biopsy was not performed)
Follow-up & recurrence
Oncological treatment (hysterectomy, radiotherapy, chemotherapy) during the follow-up period was given
Oncological treatment (hysterectomy, radiotherapy, chemotherapy) during the follow-up period
Date of treatment (month/year)
Reason
Abnormal Pap smear [No,Yes]
Cervical cancer recurrence [No,Yes]
Cervical stenosis/hematometra [No,Yes]
Doctor's decision (no disease suspected) [No,Yes]
HPV positivity [No,Yes]
Other [No,Yes]
Patient's decision (no disease suspected) [No,Yes]
Pre-cancer-recurrence (any proven LSIL, HSIL or AIS) [No,Yes]
Second cancer (endometrial, ovarian etc.) [No,Yes]
Type of treatment
Chemotherapy [No,Yes]
Hysterectomy [No,Yes]
Radiotherapy [No,Yes]
Follow-up procedure
Biopsy [No,Yes]
1. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
2. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
3. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
4. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
5. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
CT [No,Yes]
1. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
2. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
3. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
4. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
5. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
Colposcopy [No,Yes]
1. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
2. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
3. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
4. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
5. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
HPV test [No,Yes]
1. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
2. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
3. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
4. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
5. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
MRI [No,Yes]
1. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
2. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
3. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
4. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
5. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
Others [No,Yes]
Procedures description
PET-CT [No,Yes]
1. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
2. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
3. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
4. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
5. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
Pap smear [No,Yes]
1. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
2. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
3. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
4. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
5. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
Physical examination [No,Yes]
1. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
2. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
3. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
4. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
5. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
US [No,Yes]
1. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
2. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
3. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
4. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
5. year [No,Yes]
If clinically indicated [No,Yes]
Routinely [No,Yes]
Frequency every
Date of last follow-up (month/year)
Pregnancy after primary treatment
Attempt to concieve [No,Yes]
More than 6 months [No,Yes]
Way of conception
IVF program [No,Yes]
Natural [No,Yes]
Pregnancy after treatment
Number of pregnancies
Number of abortions
Number of deliveries
Profylactic management during pregnancy [No,Yes]
Antibiotic treatment [No,Yes]
None [No,Yes]
Other [No,Yes]
Description of the profylactic procedure
Preventive hospitalisation [No,Yes]
Profylactic cerclage during pregnancy [No,Yes]
Profylactic tocolytic therapy [No,Yes]
Progesterone administration [No,Yes]
Regular US cervicometry [No,Yes]
Delivery (complete repeatedly for each delivery) [No,Yes]
1. delivery [No,Yes]
Method of delivery
Date of delivery (month/year)
2. delivery [No,Yes]
Method of delivery
Date of delivery (month/year)
3. delivery [No,Yes]
Method of delivery
Date of delivery (month/year)
4. delivery [No,Yes]
Method of delivery
Date of delivery (month/year)
5. delivery [No,Yes]
Method of delivery
Date of delivery (month/year)
Recurrence
Pre-cancer recurrence during the follow-up [No,Yes]
Pre-cancer histotype
Cancer recurrence [No,Yes]
Disease free interval (DFI)
Location
Cervix [No,Yes]
Distant - others [No,Yes]
Description
Distant abdomen [No,Yes]
Distant thorax [No,Yes]
Paraaortic lymph nodes [No,Yes]
Parametrium [No,Yes]
Pelvic lymph nodes [No,Yes]
Pelvis - others [No,Yes]
Description
Vagina [No,Yes]
Symptoms of recurrence [No,Yes]
Description
Main (or first) method(s) of recurrence detection
Biopsy [No,Yes]
CT [No,Yes]
Clinical symptoms [No,Yes]
Colposcopy [No,Yes]
Cytology [No,Yes]
Gynecological examination [No,Yes]
HPV test [No,Yes]
MRI [No,Yes]
Others [No,Yes]
Description of procedures
PET-CT [No,Yes]
Physical examination [No,Yes]
US [No,Yes]
Current status
Date of death (month/year)
Cause of death
